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Several big projects have sequenced the same tumours at different times and places, but their data sit apart. Bringing them together with common analysis would show general rules of how cancers evolve.
TRACERx, PEACE, Hartwig, PCAWG and dozens of institutional cohorts hold multi-region or longitudinal genomes with treatment history, each analysed with different phylogeny tools. A federated atlas with a common clonal-reconstruction pipeline, harmonised treatment annotations and an open query interface would allow questions such as which drivers are always truncal, which resistance routes are convergent, and how fast clones expand under each drug.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Data silos, Cancer Research UK.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares Broad Institute of MIT and Harvard, Whole-exome & whole-genome sequencing.
Shares The Francis Crick Institute, Data silos, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares Broad Institute of MIT and Harvard, Cancer Research UK.
Shares Broad Institute of MIT and Harvard, Whole-exome & whole-genome sequencing.