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Almost all cancer deaths are caused by spread, yet metastatic tissue is rarely studied because rapid autopsy programmes exist at only a handful of centres. A funded 20-site network with one protocol, one consent framework and open sample access would collect donated tissue within hours of death.
Rapid autopsy programmes at a handful of centres have produced disproportionate insight into metastatic evolution and treatment resistance, but they are small, precariously funded and not interoperable. A funded 20-site network with a shared protocol, single consent framework, common data commons and open sample access would industrialise the most information-dense sample type in oncology.
Shares cBioPortal for Cancer Genomics, AACR Project GENIE, Metastasis is understood least and studied last, Data silos.
Shares cBioPortal for Cancer Genomics, AACR Project GENIE, Data silos, Whole-exome & whole-genome sequencing.
Shares TCGA / NCI Genomic Data Commons, Single-cell & spatial profiling, Data silos.
Shares cBioPortal for Cancer Genomics, AACR Project GENIE, Single-cell & spatial profiling, Data silos.
Shares Proteomics & phosphoproteomics, Single-cell & spatial profiling.
Shares AACR Project GENIE, Data silos, Whole-exome & whole-genome sequencing.
Shares Metastasis is understood least and studied last, Single-cell & spatial profiling, Whole-exome & whole-genome sequencing.
Shares Charles Swanton, Single-cell & spatial profiling, Data silos, Whole-exome & whole-genome sequencing.