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The detailed molecular maps of tumours being built today mostly lack information on what happened to the patient. Require every atlas sample to carry consented outcome data.
The Human Tumor Atlas Network and similar single-cell and spatial efforts produce rich molecular maps, but clinical annotation is thin and outcome follow-up rare. The proposal requires atlas funding to include consent for registry linkage and a minimum clinical data set (mCODE), with outcome updates pushed annually, so that cell states discovered can be tested as prognostic and predictive markers without new cohorts.
Shares TCGA / NCI Genomic Data Commons, Single-cell & spatial profiling, Data silos.
Shares CZ CELLxGENE / Human Cell Atlas, Single-cell & spatial profiling, Data silos.
Shares CZ CELLxGENE / Human Cell Atlas, Single-cell & spatial profiling.
Shares CZ CELLxGENE / Human Cell Atlas, Single-cell & spatial profiling.
Shares Data silos, Biomarkers are not validated or standardised.
Shares Single-cell & spatial profiling, Biomarkers are not validated or standardised.
Shares CZ CELLxGENE / Human Cell Atlas, Single-cell & spatial profiling.