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AACR Project GENIE
AACR Project GENIE is real-world tumour sequencing data shared by leading cancer centres.
Overview
AACR Project GENIE holds clinico-genomic data on more than 200,000 sequenced tumours contributed by 19 institutions, making it a real-world tumour sequencing resource shared by leading cancer centres. The data are open through cBioPortal and Synapse, and the project is run by the American Association for Cancer Research (AACR). Its Biopharma Collaborative adds detailed outcomes for non-small cell lung, colorectal, breast, prostate, pancreatic and bladder cancers. On OnCo it is linked to the term Real-world evidence and cited by the bottlenecks Tumour heterogeneity and clonal evolution, Acquired resistance to every therapy, Data silos and Secrecy and intellectual property block collaboration, and by ideas such as Emulate the trial in real-world data first to decide which trials to run.
Holds
Clinico-genomic data on >200,000 sequenced tumours from 19 institutions.
Licence
Open (via cBioPortal and Synapse)
Maintainer
AACR
Dataset registry
Size: More than 200,000 sequenced tumours from 19 institutions
Access: registered
Consent and reuse: De-identified clinico-genomic data via cBioPortal and Synapse; Biopharma Collaborative adds outcomes.
All datasets and the models trained on them →Similar pages
- CollectioncBioPortal for Cancer Genomics
Shares OncoTree cancer classification, A global rapid tissue donation network for metastatic disease, Let patients themselves donate their records and samples for ultra-rare cancers, An organotropism atlas that predicts where a cancer will spread.
- CollectionSEER (Surveillance, Epidemiology, and End Results)
Shares Emulate the trial in real-world data first to decide which trials to run, Link every national cancer registry to tumour genomics, An organotropism atlas that predicts where a cancer will spread, Randomise inside the registry that already follows every patient.
- CollectionOncoKB
Shares Every tumour genomic report machine-readable and deposited nationally, Pool every immunotherapy trial's biomarker data into one commons, Check whether a tumour can still show itself to the immune system.
- IdeaUniversal tumour and germline sequencing at diagnosis feeding a shared learning system
Shares American Association for Cancer Research (AACR), Real-world evidence, Data silos.
- IdeaTreat resistance like an infectious disease and run national surveillance
Shares Real-world evidence, Data silos, Acquired resistance to every therapy.
- Key paperRare cancers are not so rare: the rare cancer burden in Europe
Shares Let patients themselves donate their records and samples for ultra-rare cancers, Randomise inside the registry that already follows every patient.
- CollectionTCGA / NCI Genomic Data Commons
Shares A global rapid tissue donation network for metastatic disease, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico, Data silos.
- CompanyFoundation Medicine (Roche)
Shares Emulate combination trials from real-world data to triage which ones to run, Every tumour genomic report machine-readable and deposited nationally, Data silos.
institutions
terms
roadmaps
ideas
A global rapid tissue donation network for metastatic diseaseAn organotropism atlas that predicts where a cancer will spreadCheck whether a tumour can still show itself to the immune systemEmulate combination trials from real-world data to triage which ones to runEmulate the trial in real-world data first to decide which trials to runEvery tumour genomic report machine-readable and deposited nationallyLet patients themselves donate their records and samples for ultra-rare cancersLink every national cancer registry to tumour genomicsPool every immunotherapy trial's biomarker data into one commonsRandomise inside the registry that already follows every patientValidate real-world progression endpoints so pragmatic trials can use them
bottlenecks
journals
Open-source projects
All open source in oncology →Open-source projects that are the code behind this collection or publish it, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
Sage Bionetworks' code that harmonises the AACR GENIE clinico-genomic registry releases.