{"entity":{"id":"nilutamide","kind":"drug","name":"Nilutamide","aka":["Anandron"],"tldr":"Nilutamide (Nilandron) is an older antiandrogen tablet started on the day of surgical castration for metastatic prostate cancer; it is rarely used now because of lung and eye side effects.","summary":"Nilutamide was approved in 1996 for metastatic (stage D2) prostate cancer in combination with surgical castration, with treatment beginning on the day of or the day after orchiectomy, on a randomised trial in which the combination modestly delayed progression compared with castration alone. It has been superseded by bicalutamide and the second-generation antiandrogens. Interstitial pneumonitis (about 2% of patients, more in Japanese men) carries a boxed warning; delayed dark adaptation, alcohol intolerance and hepatitis are also characteristic.","status":"approved","asOf":"2026-09-10","wikipedia":"https://en.wikipedia.org/wiki/Nilutamide","links":[{"label":"US label (DailyMed)","url":"https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=nilutamide"},{"label":"NCI drug page","url":"https://www.cancer.gov/about-cancer/treatment/drugs/nilutamide"}],"tags":["nci-list","generic"],"related":["flutamide","bicalutamide"],"cancers":["prostate"],"sections":[],"technologies":["androgen-deprivation"],"targets":["androgen-receptor"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct03678025","nct00003653","nct00002633"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"Nilandron","modality":"Non-steroidal antiandrogen (first generation)","mechanism":"Competitive androgen receptor antagonist without oestrogenic, progestational or glucocorticoid activity.","approvals":[{"region":"US","year":1996,"indication":"Metastatic (stage D2) prostate cancer in combination with surgical castration"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/nilutamide/","neighbours":{"drug":[{"id":"bicalutamide","kind":"drug","name":"Bicalutamide","route":"/drugs/bicalutamide/"},{"id":"flutamide","kind":"drug","name":"Flutamide","route":"/drugs/flutamide/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"androgen-deprivation","kind":"technology","name":"Androgen deprivation & AR pathway inhibitors","route":"/technologies/androgen-deprivation/"}],"target":[{"id":"androgen-receptor","kind":"target","name":"Androgen receptor","route":"/targets/androgen-receptor/"}],"trial":[{"id":"nct00003653","kind":"trial","name":"Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer","route":"/trials/nct00003653/"},{"id":"nct00002633","kind":"trial","name":"Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer","route":"/trials/nct00002633/"},{"id":"nct03678025","kind":"trial","name":"Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer","route":"/trials/nct03678025/"}]}}