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Some cancer pills are absorbed several times better with food, but the label says take them fasting at a high dose. Taking a quarter of the dose with breakfast can give the same drug levels at a quarter of the price.
Randomised PK and non-inferiority trials of low-dose-with-food versus standard fasting dosing for oral agents with large positive food effects (abiraterone is the established example; others include several kinase inhibitors), followed by label changes and guideline adoption. Regulators accept PK-bridged non-inferiority; payers fund the trials because savings are immediate.
Shares Wrong doses, Prices and value.
Shares Androgen deprivation & AR pathway inhibitors, Prostate cancer.
Shares Wrong doses, Prices and value, Small-molecule kinase inhibitors.
Shares Androgen deprivation & AR pathway inhibitors, Prostate cancer.
Shares Androgen deprivation & AR pathway inhibitors, Prostate cancer.