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People differ several-fold in how they absorb and clear cancer pills. Measure blood levels and adjust each person's dose, as is routine for some antibiotics and transplant drugs.
Exposure to oral kinase inhibitors and endocrine agents varies widely between patients and correlates with both toxicity and efficacy (imatinib, abiraterone, tamoxifen metabolites, sunitinib). Therapeutic drug monitoring is standard in other fields but rare in oncology. The proposal is a programme defining exposure targets for the top 30 oral anticancer drugs, a low-cost assay network, and model-informed precision dosing software integrated into prescribing, tested in randomised trials against fixed dosing.
Shares Wrong doses, Imatinib, Endocrine therapy (SERMs, AIs, SERDs), Toxicity and quality of life are undervalued.
Shares Wrong doses, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Imatinib, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Imatinib, Small-molecule kinase inhibitors.
Shares Wrong doses, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Toxicity and quality of life are undervalued.