Loading
Blood levels of oral cancer pills vary several-fold between people on the same dose, so some are under-treated and others poisoned. Checking levels and adjusting the dose, as is routine for some antibiotics, could fix both.
Therapeutic drug monitoring (TDM) for oral kinase inhibitors and hormonal agents with established exposure-response relationships and high inter-patient variability (imatinib, sunitinib, pazopanib, abiraterone, tamoxifen via endoxifen, and newer agents), with dose adjustment to a target trough. Dutch multicentre TDM studies have shown feasibility and increased target attainment; outcome-powered randomised trials are lacking.
Shares Wrong doses, Imatinib, Endocrine therapy (SERMs, AIs, SERDs), Toxicity and quality of life are undervalued.
Shares Wrong doses, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Imatinib, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Imatinib, Small-molecule kinase inhibitors.
Shares Wrong doses, Toxicity and quality of life are undervalued, Small-molecule kinase inhibitors.
Shares Wrong doses, Toxicity and quality of life are undervalued.