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ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
May be involved in transcriptional regulation.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, animal model 0.52, genetic association 0.67).
In plain words · ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
No product in this corpus aims at ZBTB10 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2001. Earliest sequence paper UniProt cites for the protein: Kashuba V.I. et al, 2001. Source.
Sources: HGNC HGNC:30953 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96DT7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205189 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: basal cell carcinoma 0.51 (GraphQL API, CC0))
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
Query for this target: (TITLE:"ZBTB10" OR ABSTRACT:"ZBTB10" OR TITLE:"zinc finger and BTB domain containing 10" OR ABSTRACT:"zinc finger and BTB domain containing 10" OR TITLE:"Zinc finger and BTB domain-containing protein 10" OR ABSTRACT:"Zinc finger and BTB domain-containing protein 10" OR TITLE:"RINZF" OR ABSTRACT:"RINZF" OR TITLE:"FLJ12752" OR ABSTRACT:"FLJ12752") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZBTB10, not a curated reading list.