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PTPN14 (Tyrosine-protein phosphatase non-receptor type 14) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.94, animal model 0.34, genetic association 0.60, somatic mutation 0.61). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Basal Cell Carcinoma.
In plain words · PTPN14 (Tyrosine-protein phosphatase non-receptor type 14) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.
PTPN14 (Tyrosine-protein phosphatase non-receptor type 14) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition.
No product in this corpus aims at PTPN14 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1995. Earliest sequence paper UniProt cites for the protein: Smith A.L. et al, Biochem. Biophys. Res. Commun, 1995, "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Source.
Sources: HGNC HGNC:9647 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15678 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000152104 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0)); IntOGen PTPN14 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumour suppressor. Location: Cytoplasm; Cytoplasm, cytoskeleton; Nucleus (UniProt). Locus 1q32.3-q41 (HGNC).
Query for this target: (TITLE:"PTPN14" OR ABSTRACT:"PTPN14" OR TITLE:"protein tyrosine phosphatase non-receptor type 14" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 14" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 14" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 14" OR TITLE:"PTPD2" OR ABSTRACT:"PTPD2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN14, not a curated reading list.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen, Open Targets Platform.