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CPEB3 (Cytoplasmic polyadenylation element-binding protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Basal Cell Carcinoma.
In plain words · CPEB3 (Cytoplasmic polyadenylation element-binding protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.
CPEB3 (Cytoplasmic polyadenylation element-binding protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator.
No product in this corpus aims at CPEB3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1999. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:21746 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NE35 (protein name, function text, keywords and locations (REST API)); IntOGen CPEB3 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. Location: Cytoplasm; Nucleus; Synapse; Cell projection, dendrite (UniProt). Locus 10q23.32 (HGNC).
Query for this target: (TITLE:"CPEB3" OR ABSTRACT:"CPEB3" OR TITLE:"cytoplasmic polyadenylation element binding protein 3" OR ABSTRACT:"cytoplasmic polyadenylation element binding protein 3" OR TITLE:"Cytoplasmic polyadenylation element-binding protein 3" OR ABSTRACT:"Cytoplasmic polyadenylation element-binding protein 3" OR TITLE:"KIAA0940" OR ABSTRACT:"KIAA0940") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CPEB3, not a curated reading list.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen.