{"entity":{"id":"cpeb3","kind":"target","name":"CPEB3","aka":["cytoplasmic polyadenylation element binding protein 3","Cytoplasmic polyadenylation element-binding protein 3","KIAA0940"],"tldr":"CPEB3 (Cytoplasmic polyadenylation element-binding protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.","summary":"Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Basal Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21746","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21746"},{"label":"UniProt Q8NE35","url":"https://www.uniprot.org/uniprotkb/Q8NE35/entry"},{"label":"NCBI Gene 22849","url":"https://www.ncbi.nlm.nih.gov/gene/22849"},{"label":"Ensembl ENSG00000107864","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107864"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CPEB3","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:21746","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21746","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NE35","url":"https://www.uniprot.org/uniprotkb/Q8NE35/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CPEB3","url":"https://www.intogen.org/search?gene=CPEB3","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:21746","ensembl":"ENSG00000107864","uniprot":"Q8NE35","entrez":"22849","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10231032/","biology":"Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. Location: Cytoplasm; Nucleus; Synapse; Cell projection, dendrite (UniProt). Locus 10q23.32 (HGNC).","whereFound":["Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cpeb3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"}]}}