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NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration.
IntOGen calls it a driver in 4 cohorts (2 activating, 0 loss-of-function), covering Basal Cell Carcinoma, Bladder Urothelial Carcinoma, Melanoma.
In plain words · NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.
NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes.
No product in this corpus aims at NACA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:7629 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt E9PAV3 (protein name, function text, keywords and locations (REST API)); IntOGen NACA (driver in 4 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organised assembly of thick and thin filaments of myofibril sarcomeres. Location: Cytoplasm; Nucleus (UniProt). Locus 12q13.3 (HGNC).
Query for this target: (TITLE:"NACA" OR ABSTRACT:"NACA" OR TITLE:"nascent polypeptide associated complex subunit alpha" OR ABSTRACT:"nascent polypeptide associated complex subunit alpha" OR TITLE:"Nascent polypeptide-associated complex subunit alpha, muscle-specific form" OR ABSTRACT:"Nascent polypeptide-associated complex subunit alpha, muscle-specific form" OR TITLE:"NACA1" OR ABSTRACT:"NACA1" OR TITLE:"Alpha-NAC" OR ABSTRACT:"Alpha-NAC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NACA, not a curated reading list.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, IntOGen, Melanoma.
Shares Basal cell carcinoma, IntOGen.
Shares Basal cell carcinoma, Melanoma.
Shares Basal cell carcinoma, Melanoma.
Shares Basal cell carcinoma, Melanoma.
Shares Basal cell carcinoma, Melanoma.
Shares Basal cell carcinoma, Melanoma.