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NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organised assembly of thick and thin filaments of myofibril sarcomeres. Location: Cytoplasm; Nucleus (UniProt). Locus 12q13.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"NACA" OR ABSTRACT:"NACA" OR TITLE:"nascent polypeptide associated complex subunit alpha" OR ABSTRACT:"nascent polypeptide associated complex subunit alpha" OR TITLE:"Nascent polypeptide-associated complex subunit alpha, muscle-specific form" OR ABSTRACT:"Nascent polypeptide-associated complex subunit alpha, muscle-specific form" OR TITLE:"NACA1" OR ABSTRACT:"NACA1" OR TITLE:"Alpha-NAC" OR ABSTRACT:"Alpha-NAC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NACA, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/naca.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/naca.json. Licence CC BY-NC 4.0.