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Herbert Irving Comprehensive Cancer Center, Columbia University
Columbia's Herbert Irving Comprehensive Cancer Center in Upper Manhattan has held NCI designation since 1972; its scientists defined the genetic lesions of B-cell lymphoma, discovered and named ferroptosis in 2012, and spun out the systems biology company DarwinHealth, while Dawn Hershman leads SWOG's cancer care delivery research.
Also called: HICCC
Overview
NCI-designated since 1972, the Herbert Irving Comprehensive Cancer Center is the cancer centre of Columbia University Irving Medical Center and NewYork-Presbyterian in Upper Manhattan. Riccardo Dalla-Favera defined BCL6 and the genetic lesions of B-cell lymphoma; Andrea Califano's systems biology of master regulators spun out DarwinHealth; Brent Stockwell discovered and named ferroptosis in 2012; Adolfo Ferrando dissected T-cell acute lymphoblastic leukaemia. Dawn Hershman leads SWOG's cancer care delivery research from here, and Siddhartha Mukherjee, author of The Emperor of All Maladies, runs a leukaemia laboratory. Director Anil Rustgi is a GI cancer biologist.
Location
New York, NY, US
Type
cancer center · Columbia University
Website
Newsweek 2026 oncology rank
Not in top 300 listing used
NCI designation
comprehensive
OnCo score
#148 · 33 points (0 Newsweek + 15 NCI + 18 from 9 linked objects) · ranking
Research output
From OpenAlex, oncology works in the last five years (2022 to 2026, current year in progress); counted on 2026-10-01.
Matched to Columbia University, including child institutions. 1,218 works · 17,201 citations · 70% open access · 7% clinical trials · 2% reviews.
Oncology works per year
2712022
2742023
2672024
2442025
1622026
Most works
- Dawn L. Hershman68 works
- Ran Reshef48 works
- Alfred I. Neugut31 works
- Jason Dennis Wright27 works
- Andrea Califano25 works
- Gulam Abbas Manji23 works
- Benjamin Izar23 works
- Parisa Tehranifar20 works
- Michael D. Kluger20 works
- Katherine D. Crew20 works
Most cited
- Lymphoma and leukaemia genetics
- Systems biology
- Ferroptosis
- Cancer care delivery (SWOG)
Andrew B. Lassman
Chief of Neuro-Oncology, Columbia University Irving Medical Center
GlioblastomaAntibody-drug conjugatesNeuro-oncology trials
New York neuro-oncologist who led INTELLANCE-1, the trial that tested the EGFR-directed antibody-drug conjugate depatuxizumab mafodotin in newly diagnosed glioblastoma and found it did not extend survival.
Herbert Irving
Sysco co-founder whose family gave more than $900 million to Columbia, founding the Herbert Irving Comprehensive Cancer Center
Cancer centre buildingCancer genomicsEstate philanthropy
Herbert and Florence Irving's gifts to Columbia began with $8.5 million in 1987, founded its cancer centre in 1995 and ended with a $700 million bequest in 2017 for cancer research; the total passed $900 million.
Michel Sadelain
Director, Columbia Initiative in Cell Engineering and Therapy, Columbia University Irving Medical Center
CAR T-cell engineeringGene therapySynthetic immunology
Designed the second-generation CAR with a CD28 costimulatory domain that made CAR-T therapy work.
Dawn L. Hershman
Group Co-Chair, SWOG Cancer Research Network; Professor of Medicine and Epidemiology, Columbia University
Breast cancerCancer care deliverySurvivorship
Breast oncologist who co-leads SWOG and studies adherence, toxicity, and how care is actually delivered.
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Open-source projects
All open source in oncology →Open-source projects that this organisation maintains, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
A trainable, open reproduction of AlphaFold 2 from the AlQuraishi lab, with training data released.
3,433 starslast push 2025-12-16Herbert Irving Comprehensive Cancer Center, Columbia UniversityRepositoryPaper