{"entity":{"id":"columbia-hicc","kind":"institution","name":"Herbert Irving Comprehensive Cancer Center, Columbia University","aka":["HICCC"],"tldr":"Columbia's Herbert Irving Comprehensive Cancer Center in Upper Manhattan has held NCI designation since 1972; its scientists defined the genetic lesions of B-cell lymphoma, discovered and named ferroptosis in 2012, and spun out the systems biology company DarwinHealth, while Dawn Hershman leads SWOG's cancer care delivery research.","summary":"NCI-designated since 1972, the Herbert Irving Comprehensive Cancer Center is the cancer centre of Columbia University Irving Medical Center and NewYork-Presbyterian in Upper Manhattan. Riccardo Dalla-Favera defined BCL6 and the genetic lesions of B-cell lymphoma; Andrea Califano's systems biology of master regulators spun out DarwinHealth; Brent Stockwell discovered and named ferroptosis in 2012; Adolfo Ferrando dissected T-cell acute lymphoblastic leukaemia. Dawn Hershman leads SWOG's cancer care delivery research from here, and Siddhartha Mukherjee, author of The Emperor of All Maladies, runs a leukaemia laboratory. Director Anil Rustgi is a GI cancer biologist.","asOf":"2026-09-09","links":[{"label":"Herbert Irving Comprehensive Cancer Center","url":"https://www.cancer.columbia.edu"}],"tags":[],"related":[],"cancers":["dlbcl","all-leukemia","breast-hr-positive","prostate"],"sections":["ai-computation"],"technologies":[],"targets":[],"drugs":[],"companies":["swog"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["dawn-hershman","herbert-irving","michel-sadelain"],"bottlenecks":["b-tumor-heterogeneity"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"New York, NY","country":"US","lat":40.841,"lng":-73.942,"institutionType":"cancer-center","website":"https://www.cancer.columbia.edu","nci":"comprehensive","university":"Columbia University","programs":["Lymphoma and leukaemia genetics","Systems biology","Ferroptosis","Cancer care delivery (SWOG)"]},"route":"/institutions/columbia-hicc/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"}],"company":[{"id":"swog","kind":"company","name":"SWOG Cancer Research Network","route":"/companies/swog/"}],"person":[{"id":"andrew-lassman","kind":"person","name":"Andrew B. Lassman","route":"/people/andrew-lassman/"},{"id":"dawn-hershman","kind":"person","name":"Dawn L. Hershman","route":"/people/dawn-hershman/"},{"id":"herbert-irving","kind":"person","name":"Herbert Irving","route":"/people/herbert-irving/"},{"id":"michel-sadelain","kind":"person","name":"Michel Sadelain","route":"/people/michel-sadelain/"}],"bottleneck":[{"id":"b-tumor-heterogeneity","kind":"bottleneck","name":"Tumour heterogeneity and clonal evolution","route":"/bottlenecks/b-tumor-heterogeneity/"}],"paper":[{"id":"paper-rhim-stroma-restrains-pancreatic-cancer-cell-2014","kind":"paper","name":"Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma","route":"/key-papers/paper-rhim-stroma-restrains-pancreatic-cancer-cell-2014/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}]}}