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Instead of starting a new trial for every drug pair, keep one always-open trial per cancer that new arms can join and leave, sharing the same control group.
STAMPEDE (prostate) and I-SPY 2 (breast) showed that a standing master protocol with a shared control arm can test a succession of treatments for a fraction of the cost and time of separate trials. Yet most common cancers still have no perpetual platform. The proposal is a ten-year, ring-fenced infrastructure grant per tumour type (lung, colorectal, pancreas, ovary, bladder, glioma, myeloma and others) so that the platform outlives any single sponsor or investigator.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Too many combinations to test, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Cancer Research UK, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Too many combinations to test, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trial design, endpoints and cost, Glioma & glioblastoma.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Cancer Research UK, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Cancer Research UK, Trial design, endpoints and cost.
Shares Cancer Research UK, Trial design, endpoints and cost, National Cancer Institute (NIH).