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One large trial can test aspirin, a statin, metformin and exercise at the same time by randomising each separately, answering four questions for the price of one.
A 2x2x2 factorial randomises each patient to each intervention independently, so main effects of several low-cost interventions are tested with the same participants. The Add-Aspirin trial and the earlier ATAC-style factorials show feasibility. Generic repurposing candidates have no sponsor, so factorial efficiency is the only way many will ever be tested.
Shares No incentive to repurpose cheap drugs, Cancer Research UK, Colorectal cancer.
Shares No incentive to repurpose cheap drugs, Cancer Research UK.
Shares No incentive to repurpose cheap drugs, Cancer Research UK.
Shares No incentive to repurpose cheap drugs, Colorectal cancer.
Shares Cancer Research UK, Colorectal cancer.
Shares Cancer Research UK, Colorectal cancer.