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The UK's RECOVERY trial answered questions about dexamethasone and other cheap COVID drugs within months by randomising tens of thousands of ordinary hospital patients with a two-page consent and routine-data follow-up. Cancer needs the same permanent platform to test generics such as statins, metformin, aspirin and propranolol added to standard care.
RECOVERY enrolled tens of thousands of patients with a two-page consent, minimal data collection and routine-data follow-up, delivering definitive answers on dexamethasone and others within months. Oncology has platform trials (GBM AGILE, STAMPEDE, I-SPY) but none dedicated to repurposed generics across common cancers. The proposal is a perpetual pragmatic platform in one or more national health systems, embedded in routine care, randomising patients with common cancers to standard care with or without a generic candidate (statin, metformin, propranolol, aspirin, vitamin D, low-dose naltrexone, itraconazole and others), with survival from registries as the primary outcome and arms added and dropped on interim analyses.
Shares No incentive to repurpose cheap drugs, Cancer Research UK, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Cancer Research UK, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, No incentive to repurpose cheap drugs, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on.
Shares Basket, umbrella, and platform trials, Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on, Trial design, endpoints and cost.
Shares Cancer Research UK, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, No incentive to repurpose cheap drugs, Trial design, endpoints and cost.
Shares Basket, umbrella, and platform trials, Trial design, endpoints and cost.