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Frequent tiny doses of cheap old chemotherapy pills have shown surprising benefit in some cancers. A single large trial network in India and Africa could find out where this works and where it does not.
Metronomic regimens (low-dose oral methotrexate, cyclophosphamide, celecoxib) cost a few dollars a month and need no infusion. Tata Memorial trials showed a survival benefit for metronomic maintenance in head and neck cancer, but evidence in other tumours is thin and mostly single-centre. A multi-country platform trial with a shared control arm, adding and dropping regimens and tumour types, would generate definitive answers and could be run largely by nurses.
Shares Tata Memorial Centre, Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, No incentive to repurpose cheap drugs, Global access and affordability roadmap: essential medicines and generics → biosimilars and frugal trials → reliance, pooling and homegrown innovation.
Shares Tata Memorial Centre, Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, No incentive to repurpose cheap drugs, Global access and affordability roadmap: essential medicines and generics → biosimilars and frugal trials → reliance, pooling and homegrown innovation.
Shares Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, No incentive to repurpose cheap drugs, Most of the world has almost no cancer care.
Shares Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, Global access and affordability roadmap: essential medicines and generics → biosimilars and frugal trials → reliance, pooling and homegrown innovation, Most of the world has almost no cancer care, Cytotoxic chemotherapy.
Shares Basket, umbrella, and platform trials, No incentive to repurpose cheap drugs, Trial design, endpoints and cost.
Shares Tata Memorial Centre, Most of the world has almost no cancer care, Head and neck squamous cell carcinoma.
Shares Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, No incentive to repurpose cheap drugs, Most of the world has almost no cancer care.
Shares Global access and affordability roadmap: essential medicines and generics → biosimilars and frugal trials → reliance, pooling and homegrown innovation, Most of the world has almost no cancer care, Cervical cancer.