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When five companies each run a trial against the same standard treatment in the same patients, let them pool the standard-treatment patients so fewer people are randomised to the old drug.
Concurrent trials in the same indication each recruit their own control arm on identical standard of care. A pre-agreed common data model, shared eligibility core and a neutral data custodian would let sponsors borrow concurrent (not historical) controls with regulatory pre-agreement, as pioneered by the Alzheimer's Disease EPOCH and the Bayesian borrowing frameworks in paediatric oncology.
Shares ClinicalTrials.gov, Basket, umbrella, and platform trials, Too many combinations to test.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trials enrol too few, too slowly, Pancreatic ductal adenocarcinoma.
Shares Basket, umbrella, and platform trials, Trials enrol too few, too slowly, Pancreatic ductal adenocarcinoma.
Shares ClinicalTrials.gov, Trials enrol too few, too slowly.
Shares ClinicalTrials.gov, Trials enrol too few, too slowly.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma.
Shares Basket, umbrella, and platform trials, Trials enrol too few, too slowly.