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Platform trials that test several companies' drugs against one shared control arm, such as I-SPY 2, Lung-MAP, GBM AGILE and STAMPEDE, are each built from scratch by determined individuals. A permanent non-profit sponsor holding the protocol, control arm, statistics and data, with a standard entry contract for companies, would cut the launch of a new platform from years to months.
A permanent, funded, non-profit organisation that acts as regulatory sponsor and operator for master protocols in which multiple companies contribute agents, on the model of QuantumLeap Healthcare Collaborative (I-SPY 2), the Lung-MAP public-private partnership, GBM AGILE and the UK's STAMPEDE. The sponsor holds the protocol, the shared control arm, the statistical engine and the data, and offers companies a standard entry contract with pre-agreed rights to use platform results for registration. Each platform today is built from scratch by heroic individuals; institutionalising the function lowers the cost and time of adding a new disease platform from years to months.
Shares An oncology patent pool for combination trials across companies, Secrecy and intellectual property block collaboration, Too many combinations to test.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trial design, endpoints and cost, Glioma & glioblastoma.
Shares An oncology patent pool for combination trials across companies, Secrecy and intellectual property block collaboration, Too many combinations to test.
Shares Secrecy and intellectual property block collaboration, Basket, umbrella, and platform trials, Trial design, endpoints and cost, Pancreatic ductal adenocarcinoma.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trial design, endpoints and cost, Glioma & glioblastoma.
Shares Secrecy and intellectual property block collaboration, SWOG Cancer Research Network, Too many combinations to test.
Shares Basket, umbrella, and platform trials, Too many combinations to test, Pancreatic ductal adenocarcinoma.
Shares An oncology patent pool for combination trials across companies, Secrecy and intellectual property block collaboration.