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Most mouse studies of cancer drugs do not randomise animals or blind the people measuring tumours, which inflates results. Checking and publishing which institutions do it properly would change behaviour.
The ARRIVE guidelines set minimum reporting standards for animal research, but compliance remains low and unenforced. Systematic reviews show that unblinded, unrandomised animal studies overestimate effects. Funders could commission annual audits of a random sample of animal studies they supported, scoring randomisation, blinding, sample-size justification and reporting, and publish scores by institution.
Shares Multi-laboratory preclinical trials as the standard for go/no-go decisions, Preclinical results do not reproduce.
Shares Multi-laboratory preclinical trials as the standard for go/no-go decisions, Patient-derived xenografts, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.