A troubling share of published cancer experiments use cell lines that are contaminated or mislabelled. Requiring a simple identity check before publication would stop this.
Short tandem repeat profiling costs little and detects misidentification and cross-contamination, yet compliance is patchy. Mandatory deposition of STR profiles (and, for patient-derived models, low-pass sequencing confirming donor identity and drift) at submission, checked automatically against the register of misidentified lines, would remove a known and fully solvable source of irreproducibility. Some journals already require it; enforcement is inconsistent.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.