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Underpowered mouse experiments give exaggerated positive results and uninformative negatives, and papers often show one 'representative' result out of several attempts. Funders and journals should require a pre-specified power calculation, the number of independent repeats performed, and reporting of every repeat rather than the best one.
Underpowered animal studies produce exaggerated effects when positive and are uninformative when negative. Sample-size justification is required by ARRIVE and by ethics committees in principle but is rarely checked. Funders and journals could require a pre-specified power calculation, the number of independent repeats performed, and reporting of all repeats rather than a representative one.
Shares Audit animal studies for randomisation and blinding, published by institution, Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.