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A drug that works in one laboratory's mice often fails elsewhere. Running the confirmatory animal study as a randomised, blinded, multi-laboratory trial, as stroke and amyotrophic lateral sclerosis research has done, would catch this before a human trial; oncology has no such standing infrastructure.
The confirmatory preclinical trial concept borrows randomisation, blinding, power calculation and multi-site replication from clinical research. Multi-laboratory preclinical trials have been run in stroke (the MULTI-PART approach) and in amyotrophic lateral sclerosis, and reversed several accepted findings. Oncology, where phase 2 attrition is highest, has no equivalent standing infrastructure.
Shares Estimation of clinical trial success rates and related parameters, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients, Cancer Research UK.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients, Cancer Research UK, National Cancer Institute (NIH).
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Preclinical results do not reproduce, The valley of death between lab and product.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Lab models that fail to predict what happens in patients.
Shares Estimation of clinical trial success rates and related parameters, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients, The valley of death between lab and product.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Lab models that fail to predict what happens in patients.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).