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Rare and paediatric cancers often have no cell line or xenograft anywhere in the world, so no one can test drugs on them. A funded network collecting tissue at referral centres, deriving organoids under one protocol and distributing them at cost with no reach-through rights would change that.
Rare and paediatric cancers lack cell lines and xenografts, which blocks even basic drug testing. A distributed programme would fund collection at referral centres, derive organoids and xenografts under a common protocol, characterise them genomically, and distribute them at cost with no reach-through rights. Precedents include the Human Cancer Models Initiative and paediatric preclinical testing programmes.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Patient-derived organoids, Lab models that fail to predict what happens in patients.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Patient-derived organoids, Lab models that fail to predict what happens in patients.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Patient-derived organoids, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Patient-derived organoids, Lab models that fail to predict what happens in patients, Rare and paediatric cancers without markets.
Shares Estimation of clinical trial success rates and related parameters, Patient-derived xenografts, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Patient-derived organoids, Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, National Cancer Institute (NIH), Sarcomas (soft tissue, bone, GIST).