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Many cancer lab results cannot be reproduced, and trials built on them fail. Fund an independent institute that re-runs important experiments before anyone spends millions on humans.
The Reproducibility Project: Cancer Biology found that most high-profile preclinical results replicated only partially or not at all. Trials and companies are built on unreplicated findings. The proposal is a funded, independent replication institute with standing capacity in the common cancer model systems, which re-tests findings prioritised by their influence on planned trials or investments, publishes all results, and issues a replication grade that funders, investors and ethics committees can require before first-in-human studies.
Shares Patient-derived xenografts, Preclinical results do not reproduce, The valley of death between lab and product.
Shares Patient-derived xenografts, Patient-derived organoids.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids, The valley of death between lab and product.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids, The valley of death between lab and product.
Shares Patient-derived xenografts, Patient-derived organoids.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids.
Shares Patient-derived xenografts, Preclinical results do not reproduce.
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids.