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A large share of cancer research has been done on cells that were mislabelled or contaminated. A cheap DNA fingerprint test can prove identity; journals and funders should require it.
Cross-contaminated and misidentified cell lines (the ICLAC register lists over 500) continue to be used in thousands of papers. Short tandem repeat profiling costs under a hundred dollars per line. Some journals and NIH recommend authentication; few enforce it. A mandate that every paper and grant using cell lines deposits a recent STR profile matched to Cellosaurus, with funders covering the cost, would close a known, fixable source of irreproducibility.
Shares A digital passport for every cell culture: identity, contamination status, passage number, Preclinical results do not reproduce.
Shares A digital passport for every cell culture: identity, contamination status, passage number, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Cancer Models (PDCM Finder) & HCMI, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.