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Each batch of cells used in an experiment would carry a small digital record showing when it was authenticated, tested for contamination, and how many times it had been grown, attached to the published result.
Beyond identity, mycoplasma contamination and high passage number change cell behaviour and drug sensitivity. A lightweight standard (a signed JSON record with STR match, mycoplasma test date, passage, source and thaw date) generated by lab inventory software and attached to figures or methods as a persistent identifier would make culture provenance auditable and enable meta-analyses of how provenance affects results.
Shares Barcode every reagent lot so batch effects can be traced across experiments and labs, Preclinical results do not reproduce.
Shares Every drug screen includes standard reference compounds whose performance is published, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Prove your cell lines are what you say they are, or the paper is not published, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.