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Cancer Models (PDCM Finder) & HCMI
Find a mouse or dish model that matches a tumour type or mutation.
Overview
Cancer Models (the PDCM Finder) and the Human Cancer Models Initiative (HCMI) catalogue patient-derived cancer models, PDX, organoids and cell lines, with their molecular data, so a researcher can find a mouse or dish model matching a tumour type or mutation. PDCM Finder is run by EMBL-EBI and the Jackson Laboratory, HCMI by the NCI, and both are open; HCMI distributes next-generation models with clinical annotation. On OnCo the collection is tied to the technologies Patient-derived xenografts and Patient-derived organoids and to the Drug discovery roadmap. It is cited by the bottlenecks Lab models that fail to predict what happens in patients and Preclinical results do not reproduce, and by ideas such as Score every preclinical model by how often it predicted the clinical result.
Holds
Patient-derived cancer models: PDX, organoids, cell lines, with molecular data.
Licence
Open
Maintainer
EMBL-EBI / Jackson Laboratory; NCI HCMI
Dataset registry
Size: Thousands of PDX, organoid and cell-line models across providers
Access: open
Consent and reuse: Model metadata open; models by request from providers.
All datasets and the models trained on them →Similar pages
- IdeaSet aside 3% of grant budgets to replicate findings before translation
Shares A funded organoid and PDX panel as the go/no-go gate before IND-enabling money, Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids.
- CollectionDepMap (Cancer Dependency Map)
Shares Make in vivo metastasis screens a required step in drug discovery, A public atlas of drug-pair responses across a thousand patient-derived organoids, An open model bank for the rare tumours nobody has models for, Preclinical results do not reproduce.
- IdeaA digital passport for every cell culture: identity, contamination status, passage number
Shares Prove your cell lines are what you say they are, or the paper is not published, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
- IdeaScore every model system on how well it predicted real trial results
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids, Lab models that fail to predict what happens in patients.
- IdeaEvery drug screen includes standard reference compounds whose performance is published
Shares Shared reference organoid and PDX panels that every lab can test against, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
- CompanyChampions Oncology
Shares Patient-derived xenografts, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico, Patient-derived organoids, Lab models that fail to predict what happens in patients.
- Key paperReproducibility Project: Cancer Biology found that landmark preclinical results mostly shrank or vanished on replication
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids, Lab models that fail to predict what happens in patients.
- IdeaAn independent replication institute that re-tests key preclinical cancer findings before trials
Shares Patient-derived xenografts, Preclinical results do not reproduce, Patient-derived organoids.
technologies
roadmaps
ideas
A funded organoid and PDX panel as the go/no-go gate before IND-enabling moneyA public atlas of drug-pair responses across a thousand patient-derived organoidsA universal material transfer agreement with a thirty-day defaultAn open model bank for the rare tumours nobody has models forLet patients themselves donate their records and samples for ultra-rare cancersMake in vivo metastasis screens a required step in drug discoveryProve your cell lines are what you say they are, or the paper is not publishedScore every preclinical model by how often it predicted the clinical resultShared reference organoid and PDX panels that every lab can test against