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Bacteriophage delivery uses viruses that infect bacteria, not human cells, as engineered shells whose coat proteins display tumour-homing peptides or antigens and carry drugs or vaccines. They are cheap and cannot replicate in people, but the work is preclinical: no oncology phage trial had reported efficacy by 2026, and the body clears them quickly.
Phage particles are cheap, cannot replicate in human cells, and their coat proteins can be engineered to display tumour-homing peptides or antigens; phage display already underpins several approved antibodies. As a delivery vehicle in oncology the work is preclinical, with interest in phage-displayed neoantigen vaccines and in the tumour microbiome, where intratumoural bacteria could be targeted by phage. No oncology phage-therapy trial had reported efficacy by 2026.
Engineered phage capsids display homing peptides or antigens and carry payloads; they are cleared by the reticuloendothelial system rather than infecting human cells.
Query for this technology: (TITLE:"Bacteriophage-based tumour delivery" OR ABSTRACT:"Bacteriophage-based tumour delivery") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Bacteriophage-based tumour delivery, not a curated reading list.
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Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.