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In vivo base and prime editing would rewrite a cancer's DNA letter by letter inside the body. It works in the liver for inherited disease; nobody has yet corrected a cancer this way in a person.
Base editors change a single DNA letter without cutting; prime editors write short new sequences. Both are in the clinic for inherited liver and blood disease, and base editing is used ex vivo to build allogeneic CAR-T cells. Direct in vivo correction of a cancer driver, restoring TP53 or disabling a mutant KRAS allele, had not entered human trials by September 2026: solid-tumour delivery, editing every malignant cell, and the fact that a corrected cell must still out-compete an uncorrected one are all unsolved.
A catalytically impaired Cas protein fused to a deaminase or reverse transcriptase is guided to a locus and edits it without a double-strand break; delivered by lipid nanoparticle or virus.
Query for this technology: (TITLE:"In vivo base and prime editing for cancer" OR ABSTRACT:"In vivo base and prime editing for cancer") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about In vivo base and prime editing for cancer, not a curated reading list.
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Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.