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Switching a gene off for good without changing the DNA sequence, by writing chemical marks onto it.
CRISPRoff-style effectors fuse a dead Cas protein to DNA methyltransferase and repressor domains, imposing heritable silencing that survives cell division. Tune Therapeutics and Chroma Medicine took the approach into the clinic in hepatitis B, not cancer. In oncology it is an attractive route to silence undruggable drivers such as MYC, but no oncology trial had been registered by September 2026, and silencing would have to reach essentially every tumour cell to matter.
dCas9 fused to DNMT3A/3L and KRAB deposits CpG methylation and repressive histone marks at a promoter; the silenced state is copied to daughter cells.
Query for this technology: (TITLE:"Epigenetic editing" OR ABSTRACT:"Epigenetic editing" OR TITLE:"durable gene silencing" OR ABSTRACT:"durable gene silencing") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Epigenetic editing (durable gene silencing), not a curated reading list.
Shares Programmable DNA-targeting therapeutics, Radical oncology: what could change the war by 2035, CRISPR functional genomics and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.