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Some tumours contain bacteria and fungi that shelter cancer cells and break down chemotherapy. Killing them may make treatment work.
Intratumoural bacteria have been detected in colorectal, pancreatic and other tumours. Fusobacterium nucleatum is associated with colorectal cancer progression and chemoresistance, and gammaproteobacteria can metabolise gemcitabine inside pancreatic tumours. Antibiotic and targeted antimicrobial strategies remain preclinical, complicated by the fact that broad antibiotics also damage the gut microbiome that immunotherapy depends on.
Selectively eliminating tumour-resident microbes removes drug-degrading enzymes and immunosuppressive signalling from inside the tumour.
Query for this technology: (TITLE:"Targeting the tumour's own microbes" OR ABSTRACT:"Targeting the tumour's own microbes") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Targeting the tumour's own microbes, not a curated reading list.
Shares Radical oncology: what could change the war by 2035, Cytotoxic chemotherapy and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035, Pancreatic ductal adenocarcinoma and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035, Pancreatic ductal adenocarcinoma and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.