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Folded DNA machines that open only when they touch a tumour, releasing a payload or clotting the tumour's blood supply.
DNA strands can be folded into nanoscale containers whose lids are aptamer locks that open on binding a tumour marker such as nucleolin. The best-known demonstration delivered thrombin into tumour vasculature in mice, causing intravascular thrombosis and tumour necrosis; a 2024 Karolinska design displayed death-receptor ligands only at tumour pH. Nothing in this class has entered human trials, and nuclease stability and manufacturing scale remain open questions.
Scaffolded DNA origami forms a hollow structure held shut by aptamer locks; binding the trigger opens the structure and exposes the payload only where the trigger is present.
Query for this technology: (TITLE:"DNA origami nanorobots" OR ABSTRACT:"DNA origami nanorobots") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNA origami nanorobots, not a curated reading list.
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Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, radical.