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Designing a protein from scratch on a computer to grip a chosen target, instead of finding one in an animal or a library.
Deep-learning structure prediction and generative design now produce small, stable binders against chosen epitopes in weeks, including minibinders for viral and cancer targets. In oncology the first clinical examples are AI-designed antibodies rather than fully de novo scaffolds; Generate Biomedicines' MMAE-neutralising antibody entered the clinic in 2026. Designed miniproteins are attractive as ADC and radioligand targeting heads because they penetrate tissue faster than antibodies.
Diffusion and language models generate backbone geometries complementary to a target epitope; sequences are designed, expressed and screened, compressing discovery from years to weeks.
Query for this technology: (TITLE:"De novo designed protein binders" OR ABSTRACT:"De novo designed protein binders") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about De novo designed protein binders, not a curated reading list.
Shares Radical oncology: what could change the war by 2035, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico, AI-driven drug & target discovery, Targeted therapy roadmap: imatinib → designed for resistance → the undruggable drivers fall and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Radioligand therapy (beta emitters) and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
The Baker lab's diffusion model for designing new proteins and binders, with released weights.
Fast sequence design for a given protein backbone, from the Baker lab.