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Cradle
Cradle is a protein-engineering AI platform used by pharma to optimise antibodies and enzymes.
Overview
Cradle, based in Amsterdam and Zurich, is a protein engineering AI platform used by pharmaceutical companies to optimise antibodies and enzymes. It runs generative models over protein sequences with wet-lab feedback and raised a 73 million dollar Series B in 2024. OnCo links it to de novo designed protein binders. Whether AI-optimised antibodies show measurable advantages in the clinic over conventionally engineered ones is the open question. The de novo protein binder page carries the wider field.
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