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Molecular glues are small molecules that stick two proteins together so the cell destroys one of them. They are smaller and more drug-like than bifunctional degraders.
Thalidomide analogues work by gluing neosubstrates to cereblon; the field is now searching systematically for glues against chosen targets using chemoproteomics and machine learning. Monte Rosa, Nurix, C4 Therapeutics and Proxygen have clinical or near-clinical candidates against targets including cyclin K, GSPT1 and transcription factors. No purpose-designed molecular glue has been approved: the approved examples were discovered by accident decades ago.
A small molecule remodels the surface of an E3 ligase so it recognises a protein it would normally ignore, marking that protein for proteasomal destruction.
Query for this technology: (TITLE:"Molecular glue discovery platforms" OR ABSTRACT:"Molecular glue discovery platforms") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Molecular glue discovery platforms, not a curated reading list.
Shares Radical oncology: what could change the war by 2035, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico, AI-driven drug & target discovery, Targeted therapy roadmap: imatinib → designed for resistance → the undruggable drivers fall and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Drug discovery roadmap: screening in mice → maps of dependency → designing in silico and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.