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Monte Rosa Therapeutics
Molecular-glue degrader company with a GSPT1 degrader in phase 2 for AR-mutant prostate cancer and a CCNE1-directed glue in preclinical development.
Overview
MRT-2359 (GSPT1) first patient dosed in phase 2 MODeFIRe-1 with apalutamide in AR-mutation-positive mCRPC (August 2026). AACR 2026: CCNE1-directed glue degrader produced regressions in CCNE1-amplified ovarian, breast, and gastric models with better selectivity than CDK2 inhibitors. QuEEN discovery engine; Novartis and Roche partnerships.
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