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ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.
May be involved in transcriptional regulation. May play a role in spermatogenesis.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.14, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.
In plain words · ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.
ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.
May be involved in transcriptional regulation. May play a role in spermatogenesis.
No product in this corpus aims at ZNF331 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1999. Earliest sequence paper UniProt cites for the protein: Rippe et al, Genes Chromosomes Cancer, 1999, "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors". Source.
Sources: HGNC HGNC:15489 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQX6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130844 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.51 (GraphQL API, CC0)); IntOGen ZNF331 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be involved in transcriptional regulation. May play a role in spermatogenesis. Location: Nucleus (UniProt). Locus 19q13.42 (HGNC).
Query for this target: (TITLE:"ZNF331" OR ABSTRACT:"ZNF331" OR TITLE:"zinc finger protein 331" OR ABSTRACT:"zinc finger protein 331" OR TITLE:"Zinc finger protein 331" OR ABSTRACT:"Zinc finger protein 331" OR TITLE:"ZNF463" OR ABSTRACT:"ZNF463" OR TITLE:"ZNF361" OR ABSTRACT:"ZNF361") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF331, not a curated reading list.
Shares Nasopharyngeal carcinoma, Skin cancer (all types), IntOGen, Melanoma.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.