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ZNF680 (Zinc finger protein 680) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
May be involved in transcriptional regulation.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.
In plain words · ZNF680 (Zinc finger protein 680) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
ZNF680 (Zinc finger protein 680) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
No product in this corpus aims at ZNF680 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2003. Earliest sequence paper UniProt cites for the protein: Hillier L.W. et al, Nature, 2003, "The DNA sequence of human chromosome 7". Source.
Sources: HGNC HGNC:26897 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NEM1 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF680 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 7q11.21 (HGNC).
Query for this target: (TITLE:"ZNF680" OR ABSTRACT:"ZNF680" OR TITLE:"zinc finger protein 680" OR ABSTRACT:"zinc finger protein 680" OR TITLE:"Zinc finger protein 680" OR ABSTRACT:"Zinc finger protein 680" OR TITLE:"FLJ90430" OR ABSTRACT:"FLJ90430") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF680, not a curated reading list.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.