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ZNF93 (Zinc finger protein 93) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognises and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.
In plain words · ZNF93 (Zinc finger protein 93) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
ZNF93 (Zinc finger protein 93) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognises and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1.
No product in this corpus aims at ZNF93 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1991. Earliest sequence paper UniProt cites for the protein: Bellefroid E.J. et al, Proc. Natl. Acad. Sci. U.S.A, 1991, "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins". Source.
Sources: HGNC HGNC:13169 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35789 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF93 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognises and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression. Location: Nucleus (UniProt). Locus 19p12 (HGNC).
Query for this target: (TITLE:"ZNF93" OR ABSTRACT:"ZNF93" OR TITLE:"zinc finger protein 93" OR ABSTRACT:"zinc finger protein 93" OR TITLE:"Zinc finger protein 93" OR ABSTRACT:"Zinc finger protein 93" OR TITLE:"HPF34" OR ABSTRACT:"HPF34" OR TITLE:"TF34" OR ABSTRACT:"TF34" OR TITLE:"FLJ12488" OR ABSTRACT:"FLJ12488") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF93, not a curated reading list.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.