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KAT6B (Histone acetyltransferase KAT6B) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Nasopharyngeal carcinoma, Prostate cancer and 4 more.
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.89, animal model 0.28, genetic association 0.00, somatic mutation 0.87). IntOGen calls it a driver in 5 cohorts (1 activating, 4 loss-of-function), covering Invasive Breast Carcinoma, Low-Grade Glioma, NOS, Medulloblastoma, Nasopharyngeal Carcinoma, Prostate Adenocarcinoma.
In plain words · KAT6B (Histone acetyltransferase KAT6B) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Nasopharyngeal carcinoma, Prostate cancer and 4 more.
KAT6B (Histone acetyltransferase KAT6B) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Nasopharyngeal carcinoma, Prostate cancer and 4 more.
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation.
No product in this corpus aims at KAT6B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:17582 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WYB5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156650 (association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.51, skin cancer 0.55, breast cancer 0.58 (GraphQL API, CC0)); IntOGen KAT6B (driver in 5 cohorts (Act 1, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Location: Nucleus (UniProt). Locus 10q22.2 (HGNC).
Query for this target: (TITLE:"KAT6B" OR ABSTRACT:"KAT6B" OR TITLE:"lysine acetyltransferase 6B" OR ABSTRACT:"lysine acetyltransferase 6B" OR TITLE:"Histone acetyltransferase KAT6B" OR ABSTRACT:"Histone acetyltransferase KAT6B" OR TITLE:"querkopf" OR ABSTRACT:"querkopf" OR TITLE:"qkf" OR ABSTRACT:"qkf" OR TITLE:"Morf" OR ABSTRACT:"Morf") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT6B, not a curated reading list.
Shares Nasopharyngeal carcinoma, Skin cancer (all types), IntOGen, Melanoma.
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Melanoma.
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Nasopharyngeal carcinoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Nasopharyngeal carcinoma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Nasopharyngeal carcinoma, IntOGen, Breast cancer (all types), Melanoma.