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MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.
Muscle contraction.
IntOGen calls it a driver in 10 cohorts (5 activating, 5 loss-of-function), covering Acute Myeloid Leukaemia, Invasive Breast Carcinoma, Cholangiocarcinoma, Head and Neck Squamous Cell Carcinoma, Low-Grade Glioma, NOS, Melanoma and others.
In plain words · MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.
MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.
Muscle contraction. Location: Melanosome (UniProt).
No product in this corpus aims at MYH11 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1992. Earliest sequence paper UniProt cites for the protein: Okajima, 1992. Source.
Sources: HGNC HGNC:7569 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35749 (protein name, function text, keywords and locations (REST API)); IntOGen MYH11 (driver in 10 cohorts (Act 5, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Muscle contraction. Location: Melanosome (UniProt). Locus 16p13.11 (HGNC).
Query for this target: (TITLE:"MYH11" OR ABSTRACT:"MYH11" OR TITLE:"myosin heavy chain 11" OR ABSTRACT:"myosin heavy chain 11" OR TITLE:"Myosin-11" OR ABSTRACT:"Myosin-11" OR TITLE:"SMMHC" OR ABSTRACT:"SMMHC" OR TITLE:"SMMS-1" OR ABSTRACT:"SMMS-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYH11, not a curated reading list.
Shares Nasopharyngeal carcinoma, IntOGen, Breast cancer (all types), Melanoma.
Shares Nasopharyngeal carcinoma, IntOGen, Head and neck squamous cell carcinoma, Breast cancer (all types).
Shares Nasopharyngeal carcinoma, Sarcomas (soft tissue, bone, GIST), Biliary tract cancer (cholangiocarcinoma), IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen, Melanoma.
Shares Nasopharyngeal carcinoma, IntOGen, Head and neck squamous cell carcinoma, Breast cancer (all types).
Shares Nasopharyngeal carcinoma, IntOGen, Head and neck squamous cell carcinoma, Breast cancer (all types).
Shares Nasopharyngeal carcinoma, IntOGen.
Shares Nasopharyngeal carcinoma, IntOGen.