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USP9X (Ubiquitin carboxyl-terminal hydrolase 9X) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer, Hepatocellular carcinoma, Sarcomas and 5 more.
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyses 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains.
IntOGen calls it a driver in 7 cohorts (1 activating, 6 loss-of-function), covering Cholangiocarcinoma, Hepatocellular Carcinoma, Leiomyosarcoma, Nasopharyngeal Carcinoma, Prostate Adenocarcinoma, Well-Differentiated Thyroid Cancer.
In plain words · USP9X (Ubiquitin carboxyl-terminal hydrolase 9X) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer, Hepatocellular carcinoma, Sarcomas and 5 more.
USP9X (Ubiquitin carboxyl-terminal hydrolase 9X) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer, Hepatocellular carcinoma, Sarcomas and 5 more.
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins.
No product in this corpus aims at USP9X yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1996. Earliest sequence paper UniProt cites for the protein: Jones M.H. et al, Hum. Mol. Genet, 1996, "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2". Source.
Sources: HGNC HGNC:12632 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q93008 (protein name, function text, keywords and locations (REST API)); IntOGen USP9X (driver in 7 cohorts (Act 1, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyses 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signalling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. Location: Cytoplasm, cytosol; Cell projection, growth cone; Cytoplasm, cytoskeleton, cilium axoneme (UniProt). Locus Xp11.4 (HGNC).
Query for this target: (TITLE:"USP9X" OR ABSTRACT:"USP9X" OR TITLE:"ubiquitin specific peptidase 9 X-linked" OR ABSTRACT:"ubiquitin specific peptidase 9 X-linked" OR TITLE:"Ubiquitin carboxyl-terminal hydrolase 9X" OR ABSTRACT:"Ubiquitin carboxyl-terminal hydrolase 9X" OR TITLE:"DFFRX" OR ABSTRACT:"DFFRX" OR TITLE:"FAF-X" OR ABSTRACT:"FAF-X" OR TITLE:"MRX99" OR ABSTRACT:"MRX99") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about USP9X, not a curated reading list.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Nasopharyngeal carcinoma, Sarcomas (soft tissue, bone, GIST), Biliary tract cancer (cholangiocarcinoma), IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), Hepatocellular carcinoma, IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen, Prostate cancer.
Shares Papillary thyroid cancer, Thyroid cancer, Hepatocellular carcinoma, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Prostate cancer.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.