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DDX6 (Probable ATP-dependent RNA helicase DDX6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Lung cancer, Leiomyosarcoma and 1 more.
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.10, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Leiomyosarcoma, Medulloblastoma.
In plain words · DDX6 (Probable ATP-dependent RNA helicase DDX6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Lung cancer, Leiomyosarcoma and 1 more.
DDX6 (Probable ATP-dependent RNA helicase DDX6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Lung cancer, Leiomyosarcoma and 1 more.
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions.
No product in this corpus aims at DDX6 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1992. Earliest sequence paper UniProt cites for the protein: Lu et al, Nucleic Acids Res, 1992, "Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3". Source.
Sources: HGNC HGNC:2747 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P26196 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110367 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: lung cancer 0.51 (GraphQL API, CC0)); IntOGen DDX6 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Location: Cytoplasm, P-body; Cytoplasm; Nucleus; Cytoplasm, Cytoplasmic ribonucleoprotein granule (UniProt). Locus 11q23.3 (HGNC).
Query for this target: (TITLE:"DDX6" OR ABSTRACT:"DDX6" OR TITLE:"DEAD-box helicase 6" OR ABSTRACT:"DEAD-box helicase 6" OR TITLE:"Probable ATP-dependent RNA helicase DDX6" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX6" OR TITLE:"Rck/p54" OR ABSTRACT:"Rck/p54" OR TITLE:"HLR2" OR ABSTRACT:"HLR2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX6, not a curated reading list.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen, Lung cancer (all types).
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Open Targets Platform.
Shares Medulloblastoma, IntOGen, Open Targets Platform.
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Medulloblastoma, IntOGen.