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GLI1 (Transcription activator GLI1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Leiomyosarcoma.
Transcription activator that acts as a key effector of the smoothened signalling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Activated in response to smoothened signalling: in presence of hedgehog (DHH, IHH or SHH) and subsequent activation of smoothened, GLI1 translocates to the nucleus and promotes expression of target genes.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Leiomyosarcoma.
In plain words · GLI1 (Transcription activator GLI1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Leiomyosarcoma.
GLI1 (Transcription activator GLI1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Leiomyosarcoma.
Transcription activator that acts as a key effector of the smoothened signalling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract.
No product in this corpus aims at GLI1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1988. Earliest sequence paper UniProt cites for the protein: Kinzler K.W. et al, Nature, 1988, "The GLI gene is a member of the Kruppel family of zinc finger proteins". Source.
Sources: HGNC HGNC:4317 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08151 (protein name, function text, keywords and locations (REST API)); IntOGen GLI1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription activator that acts as a key effector of the smoothened signalling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Activated in response to smoothened signalling: in presence of hedgehog (DHH, IHH or SHH) and subsequent activation of smoothened, GLI1 translocates to the nucleus and promotes expression of target genes. In contrast to GLI2 and GLI3, does not contain a repressor domain and only acts as a transcription activator. Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Location: Cytoplasm; Nucleus; Cell projection, cilium (UniProt). Locus 12q13.3 (HGNC).
Query for this target: (TITLE:"GLI1" OR ABSTRACT:"GLI1" OR TITLE:"GLI family zinc finger 1" OR ABSTRACT:"GLI family zinc finger 1" OR TITLE:"Transcription activator GLI1" OR ABSTRACT:"Transcription activator GLI1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GLI1, not a curated reading list.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Basal cell carcinoma (KEGG map), Hedgehog signalling, IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Basal cell carcinoma (KEGG map), Hedgehog signalling.