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CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.
Transcriptional activator.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Leiomyosarcoma, Prostate Adenocarcinoma.
In plain words · CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.
CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.
Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt).
No product in this corpus aims at CAMTA1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:18806 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6Y1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171735 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.55, lung cancer 0.51 (GraphQL API, CC0)); IntOGen CAMTA1 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt). Locus 1p36.31-p36.23 (HGNC).
Query for this target: (TITLE:"CAMTA1" OR ABSTRACT:"CAMTA1" OR TITLE:"calmodulin binding transcription activator 1" OR ABSTRACT:"calmodulin binding transcription activator 1" OR TITLE:"Calmodulin-binding transcription activator 1" OR ABSTRACT:"Calmodulin-binding transcription activator 1" OR TITLE:"KIAA0833" OR ABSTRACT:"KIAA0833") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CAMTA1, not a curated reading list.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen, Lung cancer (all types).
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen, Prostate cancer.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.