{"entity":{"id":"camta1","kind":"target","name":"CAMTA1","aka":["calmodulin binding transcription activator 1","Calmodulin-binding transcription activator 1","KIAA0833"],"tldr":"CAMTA1 (Calmodulin-binding transcription activator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Prostate cancer, Breast cancer and 3 more.","summary":"Transcriptional activator.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Leiomyosarcoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18806","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18806"},{"label":"UniProt Q9Y6Y1","url":"https://www.uniprot.org/uniprotkb/Q9Y6Y1/entry"},{"label":"NCBI Gene 23261","url":"https://www.ncbi.nlm.nih.gov/gene/23261"},{"label":"Ensembl ENSG00000171735","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171735"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["sarcoma","prostate","breast-cancer","skin-cancer","lung-cancer","leiomyosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CAMTA1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18806","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18806","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6Y1","url":"https://www.uniprot.org/uniprotkb/Q9Y6Y1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000171735","url":"https://platform.opentargets.org/target/ENSG00000171735/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.55, lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen CAMTA1","url":"https://www.intogen.org/search?gene=CAMTA1","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:18806","ensembl":"ENSG00000171735","uniprot":"Q9Y6Y1","entrez":"23261","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10048485/","biology":"Transcriptional activator. Location: Nucleus; Cytoplasm (UniProt). Locus 1p36.31-p36.23 (HGNC).","whereFound":["Sarcomas: IntOGen driver in 1 cohort (LMS)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Leiomyosarcoma: IntOGen driver in 1 cohort (LMS)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/camta1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leiomyosarcoma","kind":"cancer","name":"Leiomyosarcoma","route":"/cancers/leiomyosarcoma/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}